Professor receives funding to improve drug manufacturing processes

8/22/2016

­UNIVERSITY PARK, Pa. – Enrique del Castillo has been awarded $270,568 by the National Science Foundation to develop statistical methods that will improve the formulation and manufacturing of drugs used to treat some of the world’s deadliest diseases.

Del Castillo, distinguished professor of industrial engineering and professor of statistics, received the funds as part of his three-year research project titled, “High Dimensional Statistical Inference in Flexible Response Surface Models for Product Formulation.”

Over the last few decades, multicomponent drugs have proved beneficial in the treatment of some of the most severe of diseases, including various cancers and HIV/AIDS. Formulating these complex drugs requires research to determine not only the component proportions and their amounts (or doses), but also the manufacturing process conditions needed for the production of such formulas.

With the introduction of new regulations by the U.S. Food and Drug Administration, drug manufacturers seeking approval of a new product or process must provide a “design space” for that product; in other words, a set of specifications regarding formulation and process operating conditions that guarantees quality. How to determine such design space poses several challenges to the pharmaceutical industry. 

In order to address these challenges, del Castillo is working to create new statistical methodology for determining optimal drug formulation and manufacturing conditions that maximize drug effectiveness. This research will be conducted in collaboration with statisticians at some of the largest pharmaceutical companies in the United States.

Beyond the pharmaceutical applications of this research, the new methods will be useful in the area of animal nutrition and evolutionary biology, given that diets have the same multicomponent form as a complex drug. They may also have implications for human nutrition and longevity studies. Del Castillo will collaborate with evolutionary biologists in the United Kingdom in this broader application of the statistical methods to be developed. 

 

Share this story:

facebook linked in twitter email

MEDIA CONTACT:

Pamela Krewson Wertz

pmk128@psu.edu 

Enrique del Castillo

Enrique del Castillo, distinguished professor of industrial engineering and professor statistics

FOR MORE INFORMATION:

Enrique del Castillo

exd13@psu.edu 

814-863-6408

Industrial and Manufacturing Engineering

 
 

About

Home of the first established industrial engineering program in the world, the Harold and Inge Marcus Department of Industrial and Manufacturing Engineering (IME) at Penn State has made a name for itself in the engineering industry through its storied tradition of unparalleled excellence and innovation in research, education, and outreach.

We are Innovators. We are Makers. We are Excellence in Engineering. We are Penn State IME.

The Harold and Inge Marcus Department of
Industrial and Manufacturing Engineering

310 Leonhard Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-865-7601

FAX: 814-863-4745